Cancerous multi-drug resistance is reduced by Leptomycin B treatment in CCRF-CEM/Taxol cellsCancerous multi-drug resistance is reduced by Leptomycin B treatment in CCRF-CEM/Taxol cells
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منابع مشابه
Continued Expression of Vinca Alkaloid Resistance by CCRF-CEM Cells after Treatment with Tunicamycin or Pronase1
We have shown that a glycoprotein(s) with a molecular weight of —180,000 exists on the surface of cultured lymphoblasts selected for resistance to vinblastine (VLB) (CEM/VLB100). The amount of this glycoprotein, which is barely detectable on the VLB-sensitive cells (GEM), appears to be related in part to the degree of resistance, up to -270-fold. Exposure of cells to Pronase for 45 to 60 min ...
متن کاملContinued expression of vinca alkaloid resistance by CCRF-CEM cells after treatment with tunicamycin or pronase.
We have shown that a glycoprotein(s) with a molecular weight of approximately 180,000 exists on the surface of cultured lymphoblasts selected for resistance to vinblastine (VLB) (CEM/VLB100). The amount of this glycoprotein, which is barely detectable on the VLB-sensitive cells (CEM), appears to be related in part to the degree of resistance, up to approximately 270-fold. Exposure of the cells ...
متن کاملLeptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation.
UNLABELLED To study the intracellular localization of MAPKAP kinase 2 (MK2), which carries a putative bipartite nuclear localization signal (NLS), we constructed a green fluorescent protein-MAPKAP kinase 2 fusion protein (GFP-MK2). In transfected cells, this protein is located predominantly in the nucleus; unexpectedly, upon stress, it rapidly translocates to the cytoplasm. This translocation c...
متن کاملMicrobial conversion products of leptomycin B.
Leptomycin B (LMB), a secondary metabolite produced by Streptomyces sp. strain ATS 1287, with known antifungal and antitumor effects, inhibits the nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 regulatory protein Rev and exhibits significant antiproliferative activity. Since LMB itself turned out to be distinctly cytotoxic, a bioconversion screening with a selected ...
متن کاملPseudomonas aeruginosa: Multi-Drug-Resistance Development and Treatment Options
Antibiotic resistance is a worldwide problem of major importance. Isolations in some countries of multi-drug-resistant (resistant to three or more classes of antimicrobials), extensively-drug-resistant (resistant to all but one or two classes) or even pan-drugresistant (resistant to all available classes) Gram-negative pathogens are causing therapeu‐ tic problems andin the same timeare posing i...
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ژورنال
عنوان ژورنال: Health
سال: 2012
ISSN: 1949-4998,1949-5005
DOI: 10.4236/health.2012.410130